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3月28日(月)　10:50〜12:00　V会場
ISMS
国際創薬シンポジウムISMS
International Symposium for Medicinal Sciences
	オーガナイザー：YOKOYAMA Yuusaku

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ISMS-PL01
Sofosbuvir: A Breakthrough Curative Therapy for the Treatment of HCV
Sofosbuvir: A Breakthrough Curative Therapy for the Treatment of HCV
シンポジスト ：	○SOFIA Michael J

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ISMS-PL02
Allosteric Modulation of GPCRs: Leveraging Signal Bias
Allosteric Modulation of GPCRs: Leveraging Signal Bias
シンポジスト ：	○LINDSLEY Craig W.

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28AB-ISMS01
Rejuvenating the Motor Driven Cargo Transport Impaired by Proteotoxicity
Rejuvenating the Motor Driven Cargo Transport Impaired by Proteotoxicity
シンポジスト ：	○BHATTACHARYYA Sanjib

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28AB-ISMS02
Novel Organic Reagents Suitable for Drug Discovery?Aminomethyl and Alkoxymethyl Trifluoroborate
Novel Organic Reagents Suitable for Drug Discovery?Aminomethyl and Alkoxymethyl Trifluoroborate
シンポジスト ：	○TANAKA Keigo、MURAI Norio、MIYANO Masayuki、YONAGA Masahiro

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28AB-ISMS03
Tissue Distribution of Teneligliptin in Rats and Comparisons with Data Reported for Other Dipeptidyl Peptidase-4 Inhibitors
Tissue Distribution of Teneligliptin in Rats and Comparisons with Data Reported for Other Dipeptidyl Peptidase-4 Inhibitors
シンポジスト ：	○NAKAMARU Yoshinobu、AKAHOSHI Fumihiko、IIJIMA Hiroaki、HISANAGA Noriko、KAWAGUCHI Atsuhiro、SUZUKI Masayuki、KUME Toshiyuki

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28AB-ISMS04
Lenvatinib Suppresses Angiogenesis Driven by VEGF and FGF through the Inhibition of both VEGFR and FGFR Signaling Pathways
Lenvatinib Suppresses Angiogenesis Driven by VEGF and FGF through the Inhibition of both VEGFR and FGFR Signaling Pathways
シンポジスト ：	○ICHIKAWA Kenji、WATANABE-MIYANO Saori、ADACHI Yusuke、YAMAMOTO Yuji、OZAWA Yoichi、FUNAHASHI Yasuhiro、OKAMOTO Kiyoshi、NOMOTO Kenichi、MATSUI Junji

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28AB-ISMS05
Identification of Predictive Gene Expression Signatures Associated with the Therapeutic Effects of Infliximab, Tocilizumab and Abatacept in Rheumatoid Arthritis
Identification of Predictive Gene Expression Signatures Associated with the Therapeutic Effects of Infliximab, Tocilizumab and Abatacept in Rheumatoid Arthritis
シンポジスト ：	○IIJIMA Hiroshi、NAKAMURA Seiji、SUZUKI Katsuya、HATA Yuko、LIM Chun Ren、ISHIZAWA Yohei、KAMEDA Hideto、AMANO Koichi、MATSUBARA Kenichi、MATOBA Ryo、TAKEUCHI Tsutomu

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28AB-ISMS06
Androprostamine A, a New Antitumor Agent for Castration Resistant Prostate Cancer
Androprostamine A, a New Antitumor Agent for Castration Resistant Prostate Cancer
シンポジスト ：	○YAMAZAKI Yohko、MASUDA Tohru、MOMOSE Isao、KAWADA Manabu、NOMOTO Akio、SHIBASAKI Masakatsu

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28AB-ISMS07
Big Data Visualization and Analysis of HTS and Broad Kinase Panel Profiling Using "Elpis Map" as a Novel User-friendly Application
Big Data Visualization and Analysis of HTS and Broad Kinase Panel Profiling Using "Elpis Map" as a Novel User-friendly Application
シンポジスト ：	○EGASHIRA Hiromu、KURONO Masakuni、KOHNO Hiroshi、YAMATSUTA Katsura、TAKEUCHI Jun、NISHIZAKI Minoru

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28AB-ISMS08
Discovery of Potent, Liver-Selective Stearoyl-CoA Desaturase-1 (SCD1) Inhibitors, Thiazole-4-acetic Acid Derivatives for the Treatment of Diabetes, Hepatic Steatosis and Obesity
Discovery of Potent, Liver-Selective Stearoyl-CoA Desaturase-1 (SCD1) Inhibitors, Thiazole-4-acetic Acid Derivatives for the Treatment of Diabetes, Hepatic Steatosis and Obesity
シンポジスト ：	○IIDA Tetsuya、UBUKATA Minoru、MITANI Ikuo、NAKAGAWA Yuichi、MAEDA Katsuya、IMAI Hiroto、OGOSHI Yosuke、HOTTA Takahiro、SAKATA Shohei、SANO Ryuhei、MORINAGA Hisayo、NEGORO Tamotsu、OSHIDA Shinichi、TANAKA Masahiro、INABA Takashi

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28AB-ISMS09
An Introduction to Excellent Center for Drug Discovery (ECDD), Mahidol University, Thailand
An Introduction to Excellent Center for Drug Discovery (ECDD), Mahidol University, Thailand
シンポジスト ：	○BORWORNPINYO Suparerk

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28AB-ISMS10
Development of Functional Monoclonal Antibodies Targeting at GPCR for Drug Discovery
Development of Functional Monoclonal Antibodies Targeting at GPCR for Drug Discovery
シンポジスト ：	○URUSHIBATA Yuji、SHIMIZU Tomoko、FUJIKAWA Kazuyo、SHINAGAWA Masahiko、SASAKI Masako、KURIBAYASHI Saya、TAKAYAMA Kiyoshi

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28AB-ISMS11
Anti Tumor Activity of Geraniin in Osteosarcoma Cells
Anti Tumor Activity of Geraniin in Osteosarcoma Cells
シンポジスト ：	○TATSUDA Daisuke、MOMOSE Isao、OHBA Shun-ichi、UMEZAWA Yoji、KAWADA Manabu、NOMOTO Akio、SHIBASAKI Masakatsu

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28AB-ISMS12
Detection of Direct Binding Interaction between Lenvatinib and Receptor Tyrosine Kinases by Chemical Probe-based Approach
Detection of Direct Binding Interaction between Lenvatinib and Receptor Tyrosine Kinases by Chemical Probe-based Approach
シンポジスト ：	○YAMAMOTO Noboru、KIMURA Takayuki、IKEMORI-KAWADA Megumi、KAMIYAMA Hiroshi、YAMAMOTO Akihiko、KOTAKE Yoshihiko、TAKASE Yasutaka、FUNAHASHI Yasuhiro、ODA Yoshiya

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28AB-ISMS13
Novel Approach for Oligonucleotide Therapeutics Development Focused on Manufacturing and Structure Improvement
Novel Approach for Oligonucleotide Therapeutics Development Focused on Manufacturing and Structure Improvement
シンポジスト ：	○SATO Hideaki、OTA Akihiro、NANKAI Hirokazu、YUYAMA Kazuhiko

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28AB-ISMS14
Therapeutic RNA Aptamer Discovery
Therapeutic RNA Aptamer Discovery
シンポジスト ：	○NONAKA Yosuke、JIN Ling、FUJIWARA Masatoshi、MIYAKAWA Shin、NAKAMURA Yoshikazu

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28AB-ISMS15
Discovery of Novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl Amino Derivatives as Orally-Bioavailable TRPV4 Antagonist for the Treatment of Pain
Discovery of Novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl Amino Derivatives as Orally-Bioavailable TRPV4 Antagonist for the Treatment of Pain
シンポジスト ：	○TSUNO Naoki、YUKIMASA Akira、YOSHIDA Osamu、SUZUKI Shinji、NAKAI Hiromi、OGAWA Tomoyuki、FUJIU Motohiro、TAKAYA Kenji、NOZU Azusa、ICHIHASHI Yusuke、INOUE Takatsugu、UENO Tatsuhiko、YAMAGUCHI Hiroki、KOBAYASHI Naotake、MATSUDA Hidetoshi

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28AB-ISMS16
Natural Lipopeptide Antibiotic Tripropeptin C Revitalizes and Synergistically Potentiates the Activity of Beta-Lactams against Methicillin-Resistant Staphylococcus aureus
Natural Lipopeptide Antibiotic Tripropeptin C Revitalizes and Synergistically Potentiates the Activity of Beta-Lactams against Methicillin-Resistant Staphylococcus aureus
シンポジスト ：	○HASHIZUME Hideki、TAKAHASHI Yoshiaki、HARADA Shigeko、IGARASHI Masayuki、NOMOTO Akio

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28AB-ISMS17
Site-specific Incorporation of Unnatural Amino Acids and Cell-free Synthesis of Proteins toward Application to Antibodies and Antigens
Site-specific Incorporation of Unnatural Amino Acids and Cell-free Synthesis of Proteins toward Application to Antibodies and Antigens
シンポジスト ：	○KATO Hiroyuki、YANAGISAWA Tatsuo、KURATANI Mitsuo、HORI Tetsuya、NISHII Wataru、TERADA Takaho、SAITO Shingo、NAKAYAMA Tomoko、UMEHARA Takashi、SAKAMOTO Kensaku、YOKOYAMA Shigeyuki

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28AB-ISMS18
Best-in-Class ALK Inhibitor: Alectinib
Best-in-Class ALK Inhibitor: Alectinib
シンポジスト ：	○AOKI Yuko、TANAKA Tomohiro、OIKAWA Nobuhiro、SAKAMOTO Hiroshi

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28AB-ISMS19
Module Technology for Oncology Drug Discovery
Module Technology for Oncology Drug Discovery
シンポジスト ：	○FUKUSHIMA Masakazu、IIZUKA Kenzo、ZHANG Chung、JIN Cheng、ESHIMA Kiyoshi

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28AB-ISMS20
Preclinical Antitumor Activity of ASP5878, a Novel Inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing Hepatocellular Carcinoma
Preclinical Antitumor Activity of ASP5878, a Novel Inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing Hepatocellular Carcinoma
シンポジスト ：	FUTAMI Takashi、OKADA Hidetsugu、KIHARA Rumi、KAWASE Tatsuya、NAKAYAMA Ayako、○SUZUKI Tomoyuki、KAMEDA Minoru、SHINDOH Nobuaki、TERASAKA Tadashi、HIRANO Masaaki、KUROMITSU Sadao

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28AB-ISMS21
Fast Identification of Novel HGK Inhibitors via Click Chemistry
Fast Identification of Novel HGK Inhibitors via Click Chemistry
シンポジスト ：	○IRIE Takayuki、FUJII Ikuo、SAWA Masaaki

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28AB-ISMS22
Identification and Optimization of a Series of Tetrahydrobenzotriazoles as Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulators that Improve Performance in a Preclinical Model of Cognition
Identification and Optimization of a Series of Tetrahydrobenzotriazoles as Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulators that Improve Performance in a Preclinical Model of Cognition
シンポジスト ：	○SHIBUGUCHI Tomoyuki、ELLARD John M、MADIN Andrew、PHILPS Oliver、HOPKIN Mark、HENDERSON Scott、BIRCH Louise、O’CONNOR Desmond、ARAI Tohru、TAKASE Kazuma、MORGAN Louise、REYNOLDS David、TALMA Sonia、HOWLEY Eimear、POWNEY Ben

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28AB-ISMS23
Identification of Anti-Neuroinflammatory Agent Effective in Alzheimer's Disease Animal Model
Identification of Anti-Neuroinflammatory Agent Effective in Alzheimer's Disease Animal Model
シンポジスト ：	ZHOU Wei、ZHONG Guifa、RAO Xiurong、ZENG Shaogao、CHI Tianyan、ZOU Libo、○HU Wenhui

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28AB-ISMS24
Hybrid Molecules of β-Carboline and Bis(hydroxymethyl)pyrrole with Topoisomerase I/II Inhibitory and DNA Cross-linking Activities Are Potent Anticancer Agents
Hybrid Molecules of β-Carboline and Bis(hydroxymethyl)pyrrole with Topoisomerase I/II Inhibitory and DNA Cross-linking Activities Are Potent Anticancer Agents
シンポジスト ：	○LEE Te-Chang、CHANG Sue-Ming、WU Ming-Hsi、CHEN Chi-Wei、SU Tsann-Long

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28AB-ISMS25
Discovery of a Potent and Orally Bioavailable GPR40 Agonist DS-1558
Discovery of a Potent and Orally Bioavailable GPR40 Agonist DS-1558
シンポジスト ：	○TAKANO Rieko、YOSHIDA Masao、INOUE Masahiro、HONDA Takeshi、NAKASHIMA Ryutaro、MATSUMOTO Koji、YANO Tatsuya、OGATA Tsuneaki、WATANABE Nobuaki、HIROUCHI Masakazu、ITO Shuichiro、YONEYAMA Tomoko、KIMURA Takako、TODA Narihiro

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28AB-ISMS26
Establishment and Application of Novel Hairless Highly Immunodeficient Mice
Establishment and Application of Novel Hairless Highly Immunodeficient Mice
シンポジスト ：	○KARIYA Ryusho、MATSUDA Kouki、TAKAHASHI Yoriko、OKADA Seiji

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28AB-ISMS27
Medicinal Chemistry in the Discovery of Perampanel (Fycompa®), as a First-in-Class Orally Active Noncompetitive AMPA Receptor Antagonist
Medicinal Chemistry in the Discovery of Perampanel (Fycompa®), as a First-in-Class Orally Active Noncompetitive AMPA Receptor Antagonist
シンポジスト ：	○NORIMINE Yoshihiko、NAGATO Satoshi、UENO Koushi、KAWANO Koki、ITO Koichi、HIBI Shigeki、HANADA Takahisa、TAKENAKA Osamu、YONAGA Masahiro

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28AB-ISMS28
Novel Epigenetic Enzyme Inhibitors for EHMT1/2
Novel Epigenetic Enzyme Inhibitors for EHMT1/2
シンポジスト ：	○MORITA Norimasa、WEGERT Anita、LEENDERS Ruben、ZIJLMANS Remco、TRIVARELLI Federica、DAMEN Eddy、MULLER Gerhard、MULLER Daniel、HEIDEMANN-DINGER Carolin、KUBBUTAT Michael

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28AB-ISMS29
Novel CDK8 Inhibitors with Long Residence Time: New Opportunities for Cancer Treatment
Novel CDK8 Inhibitors with Long Residence Time: New Opportunities for Cancer Treatment
シンポジスト ：	MEURS Pauline van、DAMEN Eddy、VEERMAN Johan、MORITA Norimasa、WEBER Holger、TOTZKE Frank、EHLERT Jan E.、SCHACHTELE Christoph、KUBBUTAT Michael H.G.、○MULLER Gerhard

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28AB-ISMS30
Structural Basis to Dissect the Binding Affinity and Specificity of Human Galectin Inhibitors
Structural Basis to Dissect the Binding Affinity and Specificity of Human Galectin Inhibitors
シンポジスト ：	○LIN Chun-Hung Hans

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28AB-ISMS31
Discovery of Novel ITK Type 1½ Inhibitors Using Fragment-based Drug Design
Discovery of Novel ITK Type 1½ Inhibitors Using Fragment-based Drug Design
シンポジスト ：	○JIKIHARA Sae、YAMAMOTO Takahiko、YASUO Kazuya、HATTORI Maki、MATSUOKA Eriko、FUJIKOSHI Chiaki、KANO Kazuya、NAGIRA Morio、ISHIDA Satoru、HIKITA Ichiro、MATSUMURA Ken-ichi、YAMAGUCHI Hiroto、HIGASHINO Kenichi

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28AB-ISMS32
Studies on Constitutive Androstane Receptor Activation of Artemisia capillaris and Coumarin Derivatives
Studies on Constitutive Androstane Receptor Activation of Artemisia capillaris and Coumarin Derivatives
シンポジスト ：	CHEN Ju-Ling、HSU Pei-Ling、CHIU Chen-Yuan、LIU Shing-Hwa、WU Tian-Shung、JUANG Shin-Hun、○HUNG Hsin-Yi

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28AB-ISMS33
ADLib® System: The Avian Cell-based Antibody Display System with Human Repertoire
ADLib® System: The Avian Cell-based Antibody Display System with Human Repertoire
シンポジスト ：	○UCHIKI Tomoaki、ASAGOSHI Kenjiro、MASUDA Hitomi、TAKAIWA Aki、SAWADA Atsushi、KOYAMA Chika、KAWATA Shigehisa、MIYAI Shunsuke、TAKAHASHI Naoki、MORIYAMA Shunsuke、YABUKI Takashi、HASHIMOTO Shu-ichi

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28AB-ISMS34
Discovery of 1,2,4-oxadiazolidine-3,5-dione Derivatives as Novel GPR40 Agonists
Discovery of 1,2,4-oxadiazolidine-3,5-dione Derivatives as Novel GPR40 Agonists
シンポジスト ：	○NEGORO Kenji、IWASAKI Fumiyoshi、YONETOKU Yasuhiro、OHNUKI Kei、KUROSAKI Toshio、KURAMOTO Kazuyuki、YOSHIDA Shigeru、TANAKA Hirotsugu、HAYASHI Masaru、KAYAKIRI Hiroshi

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28AB-ISMS35
6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors
6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors
シンポジスト ：	RAHMANI Raphae?l、BAN Kung、JONES Amy J.、FERRINS Lori、GANAME Danny、SYKES Melissa L.、AVERY Vicky M.、WHITE Karen L.、RYAN Eileen、KAISER Marcel、CHARMAN Susan A.、○BAELL Jonathan B.

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28AB-ISMS36
Hit to Lead Optimization of a New Class of Compound to Treat Human African Trypanosomiasis
Hit to Lead Optimization of a New Class of Compound to Treat Human African Trypanosomiasis
シンポジスト ：	RUSSELL Stephanie、RAHMANI Raphael、JONES Amy J.、TOYNTON Arthur、KHAJOUEI Marzieh Rahmani、NEWSON Harriet、FERRINS Lori、CHEANG Jeremy、MCNICOLL Rachel、WEAVER Don、SKELTON Brian、KAISER Marcel、RYCKER Manu de、READ Kevin、CHARMAN Susan A.

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