日本薬学会第136年会(横浜)

3月28日(譛�)　10:50��12:00　V会場

ISMS

蝗ｽ髫帛卸阮ｬ繧ｷ繝ｳ繝昴ず繧ｦ繝�ISMS

International Symposium for Medicinal Sciences

繧ｪ繝ｼ繧ｬ繝翫う繧ｶ繝ｼ�唳OKOYAMA Yuusaku

ISMS-PL01

Sofosbuvir: A Breakthrough Curative Therapy for the Treatment of HCV

Sofosbuvir: A Breakthrough Curative Therapy for the Treatment of HCV

シンポジスト：笳鬼OFIA Michael J

ISMS-PL02

Allosteric Modulation of GPCRs: Leveraging Signal Bias

Allosteric Modulation of GPCRs: Leveraging Signal Bias

シンポジスト：笳記INDSLEY Craig W.

28AB-ISMS01

Rejuvenating the Motor Driven Cargo Transport Impaired by Proteotoxicity

Rejuvenating the Motor Driven Cargo Transport Impaired by Proteotoxicity

シンポジスト：笳毅HATTACHARYYA Sanjib

28AB-ISMS02

Novel Organic Reagents Suitable for Drug Discovery窶尿minomethyl and Alkoxymethyl Trifluoroborate

Novel Organic Reagents Suitable for Drug Discovery窶尿minomethyl and Alkoxymethyl Trifluoroborate

シンポジスト：笳亀ANAKA Keigo縲｀URAI Norio縲｀IYANO Masayuki縲〆ONAGA Masahiro

28AB-ISMS03

Tissue Distribution of Teneligliptin in Rats and Comparisons with Data Reported for Other Dipeptidyl Peptidase-4 Inhibitors

Tissue Distribution of Teneligliptin in Rats and Comparisons with Data Reported for Other Dipeptidyl Peptidase-4 Inhibitors

シンポジスト：笳起AKAMARU Yoshinobu縲、KAHOSHI Fumihiko縲！IJIMA Hiroaki縲？ISANAGA Noriko縲゜AWAGUCHI Atsuhiro縲ヾUZUKI Masayuki縲゜UME Toshiyuki

28AB-ISMS04

Lenvatinib Suppresses Angiogenesis Driven by VEGF and FGF through the Inhibition of both VEGFR and FGFR Signaling Pathways

Lenvatinib Suppresses Angiogenesis Driven by VEGF and FGF through the Inhibition of both VEGFR and FGFR Signaling Pathways

シンポジスト：笳紀CHIKAWA Kenji縲仝ATANABE-MIYANO Saori縲、DACHI Yusuke縲〆AMAMOTO Yuji縲＾ZAWA Yoichi縲：UNAHASHI Yasuhiro縲＾KAMOTO Kiyoshi縲¨OMOTO Kenichi縲｀ATSUI Junji

28AB-ISMS05

Identification of Predictive Gene Expression Signatures Associated with the Therapeutic Effects of Infliximab, Tocilizumab and Abatacept in Rheumatoid Arthritis

Identification of Predictive Gene Expression Signatures Associated with the Therapeutic Effects of Infliximab, Tocilizumab and Abatacept in Rheumatoid Arthritis

シンポジスト：笳紀IJIMA Hiroshi縲¨AKAMURA Seiji縲ヾUZUKI Katsuya縲？ATA Yuko縲´IM Chun Ren縲！SHIZAWA Yohei縲゜AMEDA Hideto縲、MANO Koichi縲｀ATSUBARA Kenichi縲｀ATOBA Ryo縲ゝAKEUCHI Tsutomu

28AB-ISMS06

Androprostamine A, a New Antitumor Agent for Castration Resistant Prostate Cancer

Androprostamine A, a New Antitumor Agent for Castration Resistant Prostate Cancer

シンポジスト：笳戯AMAZAKI Yohko縲｀ASUDA Tohru縲｀OMOSE Isao縲゜AWADA Manabu縲¨OMOTO Akio縲ヾHIBASAKI Masakatsu

28AB-ISMS07

Big Data Visualization and Analysis of HTS and Broad Kinase Panel Profiling Using "Elpis Map" as a Novel User-friendly Application

Big Data Visualization and Analysis of HTS and Broad Kinase Panel Profiling Using "Elpis Map" as a Novel User-friendly Application

シンポジスト：笳畿GASHIRA Hiromu縲゜URONO Masakuni縲゜OHNO Hiroshi縲〆AMATSUTA Katsura縲ゝAKEUCHI Jun縲¨ISHIZAKI Minoru

28AB-ISMS08

Discovery of Potent, Liver-Selective Stearoyl-CoA Desaturase-1 (SCD1) Inhibitors, Thiazole-4-acetic Acid Derivatives for the Treatment of Diabetes, Hepatic Steatosis and Obesity

Discovery of Potent, Liver-Selective Stearoyl-CoA Desaturase-1 (SCD1) Inhibitors, Thiazole-4-acetic Acid Derivatives for the Treatment of Diabetes, Hepatic Steatosis and Obesity

シンポジスト：笳紀IDA Tetsuya縲ゞBUKATA Minoru縲｀ITANI Ikuo縲¨AKAGAWA Yuichi縲｀AEDA Katsuya縲！MAI Hiroto縲＾GOSHI Yosuke縲？OTTA Takahiro縲ヾAKATA Shohei縲ヾANO Ryuhei縲｀ORINAGA Hisayo縲¨EGORO Tamotsu縲＾SHIDA Shinichi縲ゝANAKA Masahiro縲！NABA Takashi

28AB-ISMS09

An Introduction to Excellent Center for Drug Discovery (ECDD), Mahidol University, Thailand

An Introduction to Excellent Center for Drug Discovery (ECDD), Mahidol University, Thailand

シンポジスト：笳毅ORWORNPINYO Suparerk

28AB-ISMS10

Development of Functional Monoclonal Antibodies Targeting at GPCR for Drug Discovery

Development of Functional Monoclonal Antibodies Targeting at GPCR for Drug Discovery

シンポジスト：笳偽RUSHIBATA Yuji縲ヾHIMIZU Tomoko縲：UJIKAWA Kazuyo縲ヾHINAGAWA Masahiko縲ヾASAKI Masako縲゜URIBAYASHI Saya縲ゝAKAYAMA Kiyoshi

28AB-ISMS11

Anti Tumor Activity of Geraniin in Osteosarcoma Cells

Anti Tumor Activity of Geraniin in Osteosarcoma Cells

シンポジスト：笳亀ATSUDA Daisuke縲｀OMOSE Isao縲＾HBA Shun-ichi縲ゞMEZAWA Yoji縲゜AWADA Manabu縲¨OMOTO Akio縲ヾHIBASAKI Masakatsu

28AB-ISMS12

Detection of Direct Binding Interaction between Lenvatinib and Receptor Tyrosine Kinases by Chemical Probe-based Approach

Detection of Direct Binding Interaction between Lenvatinib and Receptor Tyrosine Kinases by Chemical Probe-based Approach

シンポジスト：笳戯AMAMOTO Noboru縲゜IMURA Takayuki縲！KEMORI-KAWADA Megumi縲゜AMIYAMA Hiroshi縲〆AMAMOTO Akihiko縲゜OTAKE Yoshihiko縲ゝAKASE Yasutaka縲：UNAHASHI Yasuhiro縲＾DA Yoshiya

28AB-ISMS13

Novel Approach for Oligonucleotide Therapeutics Development Focused on Manufacturing and Structure Improvement

Novel Approach for Oligonucleotide Therapeutics Development Focused on Manufacturing and Structure Improvement

シンポジスト：笳鬼ATO Hideaki縲＾TA Akihiro縲¨ANKAI Hirokazu縲〆UYAMA Kazuhiko

28AB-ISMS14

Therapeutic RNA Aptamer Discovery

Therapeutic RNA Aptamer Discovery

シンポジスト：笳起ONAKA Yosuke縲゛IN Ling縲：UJIWARA Masatoshi縲｀IYAKAWA Shin縲¨AKAMURA Yoshikazu

28AB-ISMS15

Discovery of Novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl Amino Derivatives as Orally-Bioavailable TRPV4 Antagonist for the Treatment of Pain

Discovery of Novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl Amino Derivatives as Orally-Bioavailable TRPV4 Antagonist for the Treatment of Pain

シンポジスト：笳亀SUNO Naoki縲〆UKIMASA Akira縲〆OSHIDA Osamu縲ヾUZUKI Shinji縲¨AKAI Hiromi縲＾GAWA Tomoyuki縲：UJIU Motohiro縲ゝAKAYA Kenji縲¨OZU Azusa縲！CHIHASHI Yusuke縲！NOUE Takatsugu縲ゞENO Tatsuhiko縲〆AMAGUCHI Hiroki縲゜OBAYASHI Naotake縲｀ATSUDA Hidetoshi

28AB-ISMS16

Natural Lipopeptide Antibiotic Tripropeptin C Revitalizes and Synergistically Potentiates the Activity of Beta-Lactams against Methicillin-Resistant Staphylococcus aureus

Natural Lipopeptide Antibiotic Tripropeptin C Revitalizes and Synergistically Potentiates the Activity of Beta-Lactams against Methicillin-Resistant Staphylococcus aureus

シンポジスト：笳稀ASHIZUME Hideki縲ゝAKAHASHI Yoshiaki縲？ARADA Shigeko縲！GARASHI Masayuki縲¨OMOTO Akio

28AB-ISMS17

Site-specific Incorporation of Unnatural Amino Acids and Cell-free Synthesis of Proteins toward Application to Antibodies and Antigens

Site-specific Incorporation of Unnatural Amino Acids and Cell-free Synthesis of Proteins toward Application to Antibodies and Antigens

シンポジスト：笳規ATO Hiroyuki縲〆ANAGISAWA Tatsuo縲゜URATANI Mitsuo縲？ORI Tetsuya縲¨ISHII Wataru縲ゝERADA Takaho縲ヾAITO Shingo縲¨AKAYAMA Tomoko縲ゞMEHARA Takashi縲ヾAKAMOTO Kensaku縲〆OKOYAMA Shigeyuki

28AB-ISMS18

Best-in-Class ALK Inhibitor: Alectinib

Best-in-Class ALK Inhibitor: Alectinib

シンポジスト：笳帰OKI Yuko縲ゝANAKA Tomohiro縲＾IKAWA Nobuhiro縲ヾAKAMOTO Hiroshi

28AB-ISMS19

Module Technology for Oncology Drug Discovery

Module Technology for Oncology Drug Discovery

シンポジスト：笳祈UKUSHIMA Masakazu縲！IZUKA Kenzo縲〇HANG Chung縲゛IN Cheng縲・SHIMA Kiyoshi

28AB-ISMS20

Preclinical Antitumor Activity of ASP5878, a Novel Inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing Hepatocellular Carcinoma

Preclinical Antitumor Activity of ASP5878, a Novel Inhibitor of FGFR1, 2, 3 and 4, in FGF19-expressing Hepatocellular Carcinoma

シンポジスト： FUTAMI Takashi縲＾KADA Hidetsugu縲゜IHARA Rumi縲゜AWASE Tatsuya縲¨AKAYAMA Ayako縲≫雷SUZUKI Tomoyuki縲゜AMEDA Minoru縲ヾHINDOH Nobuaki縲ゝERASAKA Tadashi縲？IRANO Masaaki縲゜UROMITSU Sadao

28AB-ISMS21

Fast Identification of Novel HGK Inhibitors via Click Chemistry

Fast Identification of Novel HGK Inhibitors via Click Chemistry

シンポジスト：笳紀RIE Takayuki縲：UJII Ikuo縲ヾAWA Masaaki

28AB-ISMS22

Identification and Optimization of a Series of Tetrahydrobenzotriazoles as Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulators that Improve Performance in a Preclinical Model of Cognition

Identification and Optimization of a Series of Tetrahydrobenzotriazoles as Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulators that Improve Performance in a Preclinical Model of Cognition

シンポジスト：笳鬼HIBUGUCHI Tomoyuki縲・LLARD John M縲｀ADIN Andrew縲￣HILPS Oliver縲？OPKIN Mark縲？ENDERSON Scott縲。IRCH Louise縲＾窶僂ONNOR Desmond縲、RAI Tohru縲ゝAKASE Kazuma縲｀ORGAN Louise縲ヽEYNOLDS David縲ゝALMA Sonia縲？OWLEY Eimear縲￣OWNEY Ben

28AB-ISMS23

Identification of Anti-Neuroinflammatory Agent Effective in Alzheimer's Disease Animal Model

Identification of Anti-Neuroinflammatory Agent Effective in Alzheimer's Disease Animal Model

シンポジスト： ZHOU Wei縲〇HONG Guifa縲ヽAO Xiurong縲〇ENG Shaogao縲，HI Tianyan縲〇OU Libo縲≫雷HU Wenhui

28AB-ISMS24

Hybrid Molecules of ﾎｲ-Carboline and Bis(hydroxymethyl)pyrrole with Topoisomerase I/II Inhibitory and DNA Cross-linking Activities Are Potent Anticancer Agents

Hybrid Molecules of ﾎｲ-Carboline and Bis(hydroxymethyl)pyrrole with Topoisomerase I/II Inhibitory and DNA Cross-linking Activities Are Potent Anticancer Agents

シンポジスト：笳記EE Te-Chang縲，HANG Sue-Ming縲仝U Ming-Hsi縲，HEN Chi-Wei縲ヾU Tsann-Long

28AB-ISMS25

Discovery of a Potent and Orally Bioavailable GPR40 Agonist DS-1558

Discovery of a Potent and Orally Bioavailable GPR40 Agonist DS-1558

シンポジスト：笳亀AKANO Rieko縲〆OSHIDA Masao縲！NOUE Masahiro縲？ONDA Takeshi縲¨AKASHIMA Ryutaro縲｀ATSUMOTO Koji縲〆ANO Tatsuya縲＾GATA Tsuneaki縲仝ATANABE Nobuaki縲？IROUCHI Masakazu縲！TO Shuichiro縲〆ONEYAMA Tomoko縲゜IMURA Takako縲ゝODA Narihiro

28AB-ISMS26

Establishment and Application of Novel Hairless Highly Immunodeficient Mice

Establishment and Application of Novel Hairless Highly Immunodeficient Mice

シンポジスト：笳規ARIYA Ryusho縲｀ATSUDA Kouki縲ゝAKAHASHI Yoriko縲＾KADA Seiji

28AB-ISMS27

Medicinal Chemistry in the Discovery of Perampanel (Fycompa^®), as a First-in-Class Orally Active Noncompetitive AMPA Receptor Antagonist

Medicinal Chemistry in the Discovery of Perampanel (Fycompa^®), as a First-in-Class Orally Active Noncompetitive AMPA Receptor Antagonist

シンポジスト：笳起ORIMINE Yoshihiko縲¨AGATO Satoshi縲ゞENO Koushi縲゜AWANO Koki縲！TO Koichi縲？IBI Shigeki縲？ANADA Takahisa縲ゝAKENAKA Osamu縲〆ONAGA Masahiro

28AB-ISMS28

Novel Epigenetic Enzyme Inhibitors for EHMT1/2

Novel Epigenetic Enzyme Inhibitors for EHMT1/2

シンポジスト：笳貴ORITA Norimasa縲仝EGERT Anita縲´EENDERS Ruben縲〇IJLMANS Remco縲ゝRIVARELLI Federica縲．AMEN Eddy縲｀ﾃ廰LER Gerhard縲｀ﾃ廰LER Daniel縲？EIDEMANN-DINGER Carolin縲゜UBBUTAT Michael

28AB-ISMS29

Novel CDK8 Inhibitors with Long Residence Time: New Opportunities for Cancer Treatment

Novel CDK8 Inhibitors with Long Residence Time: New Opportunities for Cancer Treatment

シンポジスト： MEURS Pauline van縲．AMEN Eddy縲〃EERMAN Johan縲｀ORITA Norimasa縲仝EBER Holger縲ゝOTZKE Frank縲・HLERT Jan E.縲ヾCHﾃГHTELE Christoph縲゜UBBUTAT Michael H.G.縲≫雷Mﾃ廰LER Gerhard

28AB-ISMS30

Structural Basis to Dissect the Binding Affinity and Specificity of Human Galectin Inhibitors

Structural Basis to Dissect the Binding Affinity and Specificity of Human Galectin Inhibitors

シンポジスト：笳記IN Chun-Hung Hans

28AB-ISMS31

Discovery of Novel ITK Type 1½ Inhibitors Using Fragment-based Drug Design

Discovery of Novel ITK Type 1½ Inhibitors Using Fragment-based Drug Design

シンポジスト：笳徽IKIHARA Sae縲〆AMAMOTO Takahiko縲〆ASUO Kazuya縲？ATTORI Maki縲｀ATSUOKA Eriko縲：UJIKOSHI Chiaki縲゜ANO Kazuya縲¨AGIRA Morio縲！SHIDA Satoru縲？IKITA Ichiro縲｀ATSUMURA Ken-ichi縲〆AMAGUCHI Hiroto縲？IGASHINO Kenichi

28AB-ISMS32

Studies on Constitutive Androstane Receptor Activation of Artemisia capillaris and Coumarin Derivatives

Studies on Constitutive Androstane Receptor Activation of Artemisia capillaris and Coumarin Derivatives

シンポジスト： CHEN Ju-Ling縲？SU Pei-Ling縲，HIU Chen-Yuan縲´IU Shing-Hwa縲仝U Tian-Shung縲゛UANG Shin-Hun縲≫雷HUNG Hsin-Yi

28AB-ISMS33

ADLib® System: The Avian Cell-based Antibody Display System with Human Repertoire

ADLib® System: The Avian Cell-based Antibody Display System with Human Repertoire

シンポジスト：笳偽CHIKI Tomoaki縲、SAGOSHI Kenjiro縲｀ASUDA Hitomi縲ゝAKAIWA Aki縲ヾAWADA Atsushi縲゜OYAMA Chika縲゜AWATA Shigehisa縲｀IYAI Shunsuke縲ゝAKAHASHI Naoki縲｀ORIYAMA Shunsuke縲〆ABUKI Takashi縲？ASHIMOTO Shu-ichi

28AB-ISMS34

Discovery of 1,2,4-oxadiazolidine-3,5-dione Derivatives as Novel GPR40 Agonists

Discovery of 1,2,4-oxadiazolidine-3,5-dione Derivatives as Novel GPR40 Agonists

シンポジスト：笳起EGORO Kenji縲！WASAKI Fumiyoshi縲〆ONETOKU Yasuhiro縲＾HNUKI Kei縲゜UROSAKI Toshio縲゜URAMOTO Kazuyuki縲〆OSHIDA Shigeru縲ゝANAKA Hirotsugu縲？AYASHI Masaru縲゜AYAKIRI Hiroshi

28AB-ISMS35

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors

シンポジスト： RAHMANI Raphaeﾌ�l縲。AN Kung縲゛ONES Amy J.縲：ERRINS Lori縲；ANAME Danny縲ヾYKES Melissa L.縲、VERY Vicky M.縲仝HITE Karen L.縲ヽYAN Eileen縲゜AISER Marcel縲，HARMAN Susan A.縲≫雷BAELL Jonathan B.

28AB-ISMS36

Hit to Lead Optimization of a New Class of Compound to Treat Human African Trypanosomiasis

Hit to Lead Optimization of a New Class of Compound to Treat Human African Trypanosomiasis

シンポジスト： RUSSELL Stephanie縲ヽAHMANI Raphaﾃｫl縲゛ONES Amy J.縲ゝOYNTON Arthur縲゜HAJOUEI Marzieh Rahmani縲¨EWSON Harriet縲：ERRINS Lori縲，HEANG Jeremy縲｀CNICOLL Rachel縲仝EAVER Don縲ヾKELTON Brian縲゜AISER Marcel縲ヽYCKER Manu de縲ヽEAD Kevin縲，HARMAN Susan A.

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